(C) LCSB 2014 - transplanted neurons, cell replacement therapyFurther step towards a Parkinson’s cure:
Induced neural stem cells functionally integrated into mouse brain

August 2014. Scientists at the Luxembourg Centre for Systems Biomedicine (LCSB) have grafted neurons re-rogrammed from skin cells into the brains of mice for the first time with long-term stability. Six months after implantation, the neurons had become fully functionally integrated into the brain. This successful, because lastingly stable, implantation of neurons raises hope for future therapies that will replace sick neurons with healthy ones in the brains of Parkinson’s disease patients.

In their experiments Jens Schwamborn and his team of LCSB’s Developmental & Cellular Biology Group succeeded in creating stable nerve tissue in brains of adult mice from neurons that had been re-programmed from skin cells. The stem cell researchers’ technique of producing neurons, or more specifically induced neuronal stem cells (iNSC), in a petri dish from the host’s own skin cells considerably improves the compatibility of the implanted cells. The treated mice showed no adverse side effects even six months after implantation into the hippocampus and cortex regions of the brain. In fact it was quite the opposite – the implanted neurons were fully integrated into the complex network of the brain. The neurons exhibited normal activity and were connected to the original brain cells via newly formed synapses, the contact points between nerve cells. The LCSB researchers collaborated with German colleagues of Max-Planck as well as of universities Münster and Bielefeld. The results are published in the latest edition of Stem Cell reports.

Hemmer K, Zhang M, van Wüllen T, Saalem M, Tapia N, Baumuratov A, Kaltschmidt C, Kaltschmidt B, Schöler HR, Zhang W, Schwamborn JC (2014): Induced Neural Stem Cells Achieve Long-Term Survival and Functional Integration in the Adult Mouse Brain. Stem Cell Reports July 31: http://www.cell.com/stem-cell-reports/fulltext/S2213-6711%2814%2900203-3.

Source: LCSB 

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