(C) FluiCell AB 2017 BioPen workflowFluiCell: BioPen microfluidics for single-cell experiments

The ability to study and interrogate one or a small number of cells requires precision control over the environment immediately surrounding a cell. The BioPen is a unique and powerful microfluidic system for maintaining localized superfusion in single-cell experiments, enabling control of the chemical environment around single intact cells in tissue or cell cultures.

Interrogate single cells

Expose just one or a small number of cells to particular test solutions, e.g. drugs or antibodies, without diffusion outside the experimental region of interest. The test solution can easily be confined.

Rapid delivery
Deliver four different solutions to just a single cell or part of a cell with sub-second exchange time.

Low compound consumption
The four integrated solution reservoirs containing less than 35 μl, overcome typical dead volume problem of external tubing, reducing significantly the use of expensive reagents.

Combination with other probing devices
The pipette tip has been optimized to fit into practically any micromanipulation environment allowing combination with other probes such as patch-clamp pipettes, optical fibers or electrodes.

No glass or tip breakage
The pipette tips are made from a flexible biocompatible material so that unlike glass pipettes they won’t break upon contact with the hard surface.

No contamination
The pipette tip has been developed from an hydrodynamically confined flow principle, enabling contamination-free confinement of one miscible liquid inside another.

Source: FluiCell AB 

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