Systems Biology Applied

October 2011. Systems Biology need sound theoretical concepts. Massive technology set-ups won’t resolve alone the puzzle. Reflecting on Einstein’s random walk, perturbation, dissipative systems, retention, biological variation, natural drifting, thermodynamic equilibrium, phylogenetic selection, and autopoiesis,. A conversation with Prof. Rudi Balling, Director of the Luxembourg Centre for Systems Biomedicine on key concepts of systems theory. How they can mislead or fruitfully inform experimental systems biology when doing experimental work to elucidate effects of knock-out genes, siRNAs, ligand binding, lateral inhibition, to explain signal transduction, somitogenesis, genetic programming, or to quantify input-output relations for example of regulatory pathways.Reading time: 12 min

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